Company Filing History:
Years Active: 1998-1999
Title: The Innovative Contributions of Irene LaRue-Kalisz
Introduction
Irene LaRue-Kalisz is a notable inventor based in Frederick, MD (US). She has made significant contributions to the field of biomedical research, particularly in the study of HIV. With a total of 3 patents to her name, her work has the potential to impact diagnostics and vaccine development.
Latest Patents
One of her latest patents involves a human T-cell line infected with HIV-2, which secretes functionally intact viral envelope proteins. This novel cell line, chronically infected with the HIV-2.sub.NIHZ virus, allows for the growth of cells in serum-free medium, enabling a concentration of the conditioned medium to be increased by over 100 fold. This concentration step is crucial, as it is otherwise impossible to achieve under conventional conditions using 10% fetal calf serum. The patent also details a specific affinity procedure to purify the gp160 protein from the concentrated medium using a mouse monoclonal antibody to the HIV-2 gp41 protein. The purified HIV-2 gp160 has shown high specificity and sensitivity in reacting with antiviral antibodies from HIV-2 infected humans through various methods, including ELISA and western blot analysis. This innovation serves as a diagnostic tool for detecting HIV-2 infection and holds promise for developing vaccine strategies against HIV-2 in humans.
Career Highlights
Irene LaRue-Kalisz is currently associated with Akzo Nobel N.V., where she continues her research and development efforts. Her work has been instrumental in advancing our understanding of HIV and its implications for human health.
Collaborations
Irene has collaborated with notable colleagues, including Mangalasseril G Sarngadharan and Vaniambadi S Kalyanaraman, contributing to a rich environment of innovation and research.
Conclusion
Irene LaRue-Kalisz's contributions to the field of biomedical research, particularly in HIV studies, highlight her role as a pioneering inventor. Her patents not only advance scientific knowledge but also offer practical solutions for diagnostics and potential vaccine development.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.