Howard J Schaeffer

Title: Howard J Schaeffer: Innovator in Antiviral Compounds

Introduction

Howard J Schaeffer is a notable inventor based in Raleigh, NC (US). He has made significant contributions to the field of antiviral compounds, holding a total of 10 patents. His work has focused on the development of novel purine derivatives that exhibit antiviral activity against herpes viruses.

Latest Patents

Schaeffer's latest patents include groundbreaking discoveries in purine derivatives. One of his notable inventions is the novel compound 6-deoxyacyclovir, which demonstrates antiviral activity against herpes viruses. This compound is enzymatically converted to acyclovir by xanthine oxidase/dehydrogenase or aldehyde oxygenase. Additionally, he has discovered 9-hydroxyethoxymethyl derivatives of certain 6- and 2,6-substituted purines, which have shown potent antiviral activities. His patents also disclose novel compounds and their pharmaceutically acceptable salts, as well as pharmaceutical formulations containing these compounds for the treatment of viral infections. Examples of especially active compounds include 9-(2-hydroxyethoxymethyl) guanine and 2-amino-9-(2-hydroxyethoxymethyl)adenine.

Career Highlights

Schaeffer has had a distinguished career at Burroughs Wellcome Co., where he has been instrumental in advancing antiviral research. His innovative work has contributed to the development of effective treatments for viral infections, showcasing his expertise in medicinal chemistry and pharmacology.

Collaborations

Throughout his career, Schaeffer has collaborated with esteemed colleagues, including Paulo M DeMiranda and Gertrude B Elion. These collaborations have further enriched his research and contributed to the success of his inventions.

Conclusion

Howard J Schaeffer's contributions to the field of antiviral compounds have made a significant impact on medical science. His innovative work continues to pave the way for new treatments and therapies for viral infections.