Company Filing History:
Years Active: 2002-2004
Title: Innovations of Hongbin Men in Bacterial Cell Wall Biosynthesis
Introduction
Hongbin Men is a notable inventor based in Princeton, NJ (US). He has made significant contributions to the field of bacterial cell wall biosynthesis through his innovative research and patents. His work focuses on the enzymatic processes involved in this critical biological function.
Latest Patents
Hongbin Men holds 2 patents related to substrate analogs for MurG, a GlcNAc transferase. His first patent discloses general methods for monitoring the activity of MurG, which is essential for bacterial cell wall biosynthesis. The synthesis of simplified substrate analogs of Lipid I, the natural substrate for MurG, is described in detail. These analogs serve as acceptors for UDP-GlcNAc in enzymatic reactions catalyzed by MurG. Additionally, the patent outlines assays using these substrate analogs, which are useful for identifying various substrates, including inhibitors of MurG activity. High throughput assays are also included in this patent.
His second patent similarly focuses on substrate analogs that substitute for Lipid I as a substrate for MurG. It also details methods for monitoring MurG activity and the synthesis of simplified substrate analogs. The assays disclosed in this patent further facilitate mechanistic and structural studies of the enzyme.
Career Highlights
Hongbin Men is affiliated with Princeton University, where he conducts his research. His work has garnered attention for its potential applications in understanding bacterial cell wall biosynthesis and developing new therapeutic strategies.
Collaborations
He has collaborated with notable colleagues, including Suzanne Walker Kahne and Peter W Park, contributing to advancements in his field.
Conclusion
Hongbin Men’s innovative work in the area of bacterial cell wall biosynthesis through his patents highlights the importance of substrate analogs in enzymatic reactions. His contributions continue to influence research and potential applications in microbiology and pharmacology.