Holger Müller

Title: Holger Müller: Innovator in Enzymatic Determination of HbA1c

Introduction:

Holger Müller, a dedicated inventor based in Diez, Germany, has made significant contributions in the field of enzymatic determination of glycated hemoglobin (HbA1c). With a passion for developing cutting-edge techniques and reagents, Müller has earned recognition for his innovative patents that have enhanced the accuracy and stability of this crucial diagnostic process.

Latest Patents:

Müller's latest patents focus on improving the enzymatic determination of HbA1c. These patents describe a method for determining the amount of glycated hemoglobin in a sample, involving steps such as hemolysis and contacting the released hemoglobin with a proteolytic agent. The resulting glycated hemoglobin degradation products are then quantified.

In these patents, Müller's contributions are integral to ensuring the stability of key chemical compounds essential for the reaction. He proposes utilizing inactivated proteases that can be reactivated in situ as a solution to provide the required stability. In addition, he highlights the importance of suitable stabilizers present in the hemolysis solution to maintain the stability of unfolded hemoglobin at a low pH range (1 to 3). Müller also suggests the use of phosphine compounds and/or thio compounds to stabilize leuco dyes, which are employed in HbA1c determination.

Career Highlights:

Holger Müller currently works at Diasys Diagnostic Systems GmbH, a renowned company at the forefront of diagnostic solutions. Within this company, he has continued to explore innovative approaches to enzymatic determination of HbA1c, pushing the boundaries of diagnostic accuracy and reliability. His research and patents have gained recognition in the industry, establishing him as a prominent figure in his field.

Collaborations:

Throughout his career, Müller has collaborated with fellow innovators and scientists to further advance the field of enzymatic determination of HbA1c. Among his notable collaborators are Günther Gorka and Yoshifumi Watazu, who have contributed to the exploration and refinement of new techniques and reagents.

Conclusion:

Holger Müller's expertise and dedication in enzymatic determination of HbA1c have ushered in innovative advancements that enhance the accuracy and stability of this vital diagnostic process. His patents, career achievements, and collaborations with esteemed professionals demonstrate his contribution to the field of medical diagnostics. Müller's ongoing work at Diasys Diagnostic Systems GmbH ensures that the quest for improved diagnostic solutions remains at the forefront of medical innovation.