Company Filing History:
1 out of 3 
1 out of 832,912 Years Active: 1986
Title: Hisashi Mihara: Innovator in Thrombolytic Agents
Introduction
Hisashi Mihara is a notable inventor based in Miyazaki-ken, Japan. He has made significant contributions to the field of medicine, particularly in the development of thrombolytic agents derived from earthworm tissues. His innovative work has led to the discovery of novel proteases that have potential therapeutic applications.
Latest Patents
Hisashi Mihara holds 1 patent for his invention titled "Thrombolytic agent." This patent discloses that the tissues of earthworms contain fibrinolytically or thrombolytically active ingredients. These ingredients can be extracted and purified through a specific sequence of procedures, resulting in six novel proteases. The proteases are identified as F-O-HM-45, F-I-1-HM-54, F-I-2-HM-15, F-II-HM-64, F-III-1-HM-27, and F-III-2-HM-89. The invention details the chromatographic fractionation of the earthworm extract, which yields five active fractions, each containing different proteases. The patent also includes descriptions of suitable purification methods and physico-chemical identification data for the proteases. Additionally, various thrombolytic medicament forms prepared with these novel proteases are described, along with results from clinical tests conducted through oral administration.
Career Highlights
Throughout his career, Hisashi Mihara has worked with Amano Seiyaku Kabushiki Kaisha, where he has contributed to advancements in pharmaceutical research and development. His work has been instrumental in exploring the therapeutic potential of natural compounds.
Collaborations
Hisashi Mihara has collaborated with notable individuals in his field, including Hiroyuki Sumi and Akira Matsuura. These collaborations have likely enhanced the research and development of his innovative thrombolytic agents.
Conclusion
Hisashi Mihara's contributions to the field of thrombolytic agents highlight the importance of natural resources in medical advancements. His innovative work continues to pave the way for new therapeutic options in medicine.