Company Filing History:
2 out of 303 
1 out of 389 
Years Active: 2000-2021
Title: The Innovative Contributions of Hazel Sive in RNA and Protein Research
Introduction: Hazel Sive, an accomplished inventor based in Newton, MA, has made significant strides in the fields of molecular biology and genetics. With two patents to her name, she is recognized for her groundbreaking work that enhances RNA interference (RNAi) efficiency and explores the intricate roles of Frazzled proteins in cellular functions.
Latest Patents: Hazel's most recent patents demonstrate her dedication to advancing scientific knowledge and applications. The first patent, titled "Increasing RNAi efficiency through single nucleotide mismatches," outlines methods and compositions designed to enhance RNAi efficiency, which is vital for gene silencing technologies. The second patent, "Frazzled nucleotide sequences and expression products," reveals purified Frazzled proteins—including WG67-16, WG67-19, and WA628—as well as the DNA molecules that encode these proteins. These innovations hold potential for modulating the binding of Wnt genes to their receptors, thereby influencing various cellular processes such as formation, growth, differentiation, and maintenance of adult and embryonic tissues and organs.
Career Highlights: Sive's professional journey includes key roles at the Whitehead Institute for Biomedical Research and Genetics Institute, Inc. Her tenure at these prestigious institutions underscores her commitment to research and development in the biomedical field, where she has cultivated a reputation for excellence.
Collaborations: Throughout her career, Hazel has collaborated with notable professionals in the field, such as Lisa A. Racie and Edward Roland Lavallie. These partnerships have contributed to her research's success and have fostered an environment of innovation.
Conclusion: Hazel Sive's contributions to RNA and protein research highlight her innovative spirit and expertise. With her patents paving the way for advancements in molecular biology, she continues to inspire future generations of scientists and inventors in their pursuit of knowledge and breakthrough discoveries.