Harry Ostrer

Harry Ostrer is a prominent inventor based in New York, NY (US), known for his significant contributions to the field of genetics and cancer research. With a total of 8 patents, he has developed groundbreaking methods and compositions that enhance the understanding and treatment of genetic disorders related to cancer.

Latest Patents

Ostrer's latest patents focus on innovative approaches for diagnosing and treating germline mismatch repair deficiencies, particularly Lynch Syndrome. His work involves assessing germline risks of cancer associated with heritable pathogenic variants in the mismatch repair (MMR) pathway. These variants can lead to the development of colon cancer and other malignancies. His research has led to the development of flow cytometry-based functional variant assays (FVAs) that determine whether variants in MMR repair genes augment the nuclear translocation of key proteins and the downstream nuclear phosphorylation of ATM and ATR in response to DNA mismatches. The assays effectively distinguish pathogenic variants from benign controls, providing a robust method for identifying Lynch Syndrome and associated cancer risks.

Additionally, Ostrer has developed methods for determining the functional activity of DNA double-strand break repair pathway molecules. Heritable mutations in genes such as BRCA1 and BRCA2 increase the risk of breast, ovarian, and other cancers. His FVAs assess whether variants in these genes disrupt critical protein interactions and the transport of the BRCA1 complex to the nucleus in response to DNA damage. These assays can categorize variants of uncertain significance (VUS) and serve as a stand-alone measure for assessing breast cancer risk.

Career Highlights

Throughout his career, Harry Ostrer has made significant strides in the field of medical genetics. His work at the Albert Einstein College of Medicine has been instrumental in advancing the understanding of genetic factors in cancer. His innovative research has not only contributed to scientific knowledge but has also paved the way for improved diagnostic and therapeutic strategies.

Collaborations

Ostrer has collaborated with notable colleagues, including Johnny C. Loke and Alexander Pearlman, to further enhance the impact of his research. These collaborations have fostered a multidisciplinary approach to tackling complex genetic issues.

Conclusion

Harry Ostrer's contributions to the field of genetics and cancer research are invaluable. His innovative patents and collaborative efforts continue to shape the landscape of medical science, providing new insights into the diagnosis and treatment of genetic disorders

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