Company Filing History:
Years Active: 1978
Title: Harlan D Caldwell: Innovator in Medical Research
Introduction
Harlan D Caldwell is a notable inventor based in Seattle, WA (US). He has made significant contributions to the field of medical research, particularly in the area of infectious diseases. His work has led to advancements in the diagnosis and understanding of certain infections.
Latest Patents
Harlan D Caldwell holds a patent for an antigen related to trachoma lymphogranuloma venereum (LGV) and non-gonococcal infections. The patent details the solubilized antigens of C. trachomatis strain LGV-434, which, upon analysis using two-dimensional immunoelectrophoresis, yielded a single antigen. This antigen was consistently precipitated by sera from patients with C. trachomatis infections. The antigen-antibody complex was utilized as an immunogen to prepare a rabbit monospecific antiserum. This antiserum demonstrated the presence of the antigen in all 15 strains of C. trachomatis organisms while remaining non-reactive with strains of C. psittaci. The specific antigen was purified through immunoadsorption chromatography, and the resulting purified antigen was employed to detect antibodies from the sera of lymphogranuloma venereum patients using counterimmunoelectrophoresis. Furthermore, when isotopically labeled, the antigen can be used in a highly sensitive radioimmune assay for the serological diagnosis of non-gonococcal urethritis (NGU).
Career Highlights
Harlan D Caldwell has dedicated his career to advancing medical research and diagnostics. His innovative work has led to a better understanding of C. trachomatis infections and has the potential to improve diagnostic methods for non-gonococcal urethritis.
Collaborations
Harlan has collaborated with notable colleagues, including Cho-chou Kuo and George E Kenny. Their combined efforts have contributed to the advancements in the field of infectious disease research.
Conclusion
Harlan D Caldwell's contributions to medical research, particularly through his patent on C. trachomatis antigens, highlight his role as an innovator in the field. His work continues to influence the diagnosis and treatment of infectious diseases.
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