Harald Kolmar

Title: Innovations of Harald Kolmar

Introduction

Harald Kolmar is a notable inventor based in Göttingen, Germany. He has made significant contributions to the field of biotechnology, particularly in the area of peptide and polypeptide exposure on bacterial surfaces. With a total of 2 patents, Kolmar's work has implications for various applications in microbial biotechnology.

Latest Patents

One of Kolmar's latest patents is a method for exposing peptides and polypeptides on the cell surface of bacteria. This inventive method allows for the exposure of peptides or polypeptides on the surface of gram-negative host bacteria using specific intimin-based anchor modules. Intimins with shortened carboxy terminals have been identified as particularly suitable anchor modules for passenger domains in the exterior cell membrane. The method involves transforming host bacteria using vectors that contain a fused nucleic acid sequence, which codes for an intimin with a shortened carboxy terminal and a passenger peptide. This invention enables a large number of passenger domains to be exposed on the bacterial cell surface without adversely affecting the bacteria's viability.

Another significant patent by Kolmar relates to vectors for the genetic selection of ligand-binding proteins in microorganisms. This process involves presenting a ligand-binding protein extracytoplasmically and transmitting the signal of ligand binding through signal transduction to the microorganism's biosynthetic machinery. The patent also discloses suitable microorganisms for this process, as well as replicons and methods for their preparation.

Career Highlights

Throughout his career, Kolmar has worked with several prominent companies, including Nascacell Technologies AG and Behringwerke Aktiengesellschaft. His experience in these organizations has contributed to his expertise in biotechnology and innovation.

Collaborations

Kolmar has collaborated with notable individuals in his field, including Andreas Christmann and Alexander Wentzel. These collaborations have likely enhanced his research and development efforts.

Conclusion

Harald Kolmar's innovative work in biotechnology, particularly in the exposure of peptides and polypeptides on bacterial surfaces, showcases his significant contributions to the field. His patents reflect a commitment to advancing microbial biotechnology and its applications.