Hang Gyeong Chin

Title: Innovations by Hang Gyeong Chin

Introduction

Hang Gyeong Chin is an accomplished inventor based in Ipswich, MA (US). She has made significant contributions to the field of molecular biology through her innovative patent. Her work focuses on the detection of molecular targets on chromosomal DNA, which has important implications for diagnostics.

Latest Patents

Hang Gyeong Chin holds a patent titled "Compositions and methods for detecting molecular targets on chromosomal DNA." This patent describes compositions, methods, and kits designed to identify the presence and location of targets within chromosomal DNA. The invention utilizes a nicking endonuclease fused to a binding domain that can bind to a constant region of an antibody. This allows for direct binding to a target or binding via an antibody that recognizes the target. The target may represent a protein or a structural feature of the DNA, and its presence can correlate with specific phenotypes or pathologies in biopsy samples. The invention also includes a method to reduce background interference by incorporating a glycoaminoglycan that inhibits the binding of the nicking endonuclease to DNA. Additionally, the method employs nick translation with a strand displacing polymerase to incorporate tagged nucleotides, facilitating various applications such as sequencing and microscopy analysis.

Career Highlights

Hang Gyeong Chin is currently employed at New England Biolabs, Inc., where she continues to advance her research in molecular biology. Her innovative approach to detecting molecular targets has positioned her as a key figure in her field.

Collaborations

Throughout her career, Hang Gyeong Chin has collaborated with notable colleagues, including Sriharsa Pradhan and George R Feehery. These collaborations have further enhanced her research and contributed to the development of her patented technologies.

Conclusion

Hang Gyeong Chin's contributions to the field of molecular biology through her innovative patent demonstrate her expertise and commitment to advancing diagnostic methods. Her work has the potential to significantly impact the way molecular targets are detected and analyzed in various biological samples.