Company Filing History:
Years Active: 1994-2000
Title: Innovations by Gregory P Lunstrum in Keratinocyte Adhesion
Introduction
Gregory P Lunstrum, an accomplished inventor based in Portland, OR, has made significant contributions to the field of dermatological science. With a focus on improving keratinocyte adhesion to the dermis, his innovations have the potential to impact wound healing and skin regeneration. He holds three patents that showcase his dedication to advancing medical technology and therapies.
Latest Patents
Lunstrum’s latest patents revolve around products and methods aimed at enhancing the adhesion of epidermal keratinocytes to the underlying dermal substrate. One notable invention involves the use of purified kalinin, a trimeric molecule that facilitates this adhesion. Kalinin is characterized by three nonidentical chains, including a chain with the BM165 epitope, which is essential for the adhesion process. Another patent details the isolated proteins kalinin and k-laminin, which are crucial for the attachment of epidermal keratinocytes to the dermis. Kalinin has a molecular weight ranging from approximately 410 to 495 kDa and localizes to anchoring filaments of the basement membranes in various human tissues. The k-laminin adhesion molecule, an isolated heterotrimeric laminin variant with a molecular weight of about 650 kDa, also contributes to this innovative approach. Together, these elements provide a method for improving the adhesion of transplanted keratinocytes, enhancing their survival and integration into the transplant substrate.
Career Highlights
Throughout his career, Gregory P Lunstrum has worked with notable organizations, including Oregon Health & Science University and the State of Oregon. His experiences in these institutions have undoubtedly enriched his research and inventions, allowing him to collaborate closely with experts in related fields.
Collaborations
Lunstrum has collaborated with esteemed colleagues such as Douglas R Keene and M Peter Marinkovich. These collaborations have fostered an environment of innovative thinking and have contributed to the successful development of his patents.
Conclusion
Gregory P Lunstrum’s work in the field of keratinocyte adhesion illustrates his commitment to enhancing medical therapies through innovation. His patents serve as a testament to his role as a pioneering inventor, with potential implications for improved treatments in dermatology and regenerative medicine. As research continues, Lunstrum's inventions may pave the way for significant advancements in the field, ultimately benefiting patients in need of effective skin therapies.