Location History:
- Tantallon, MD (US) (1976 - 1979)
- Rockville, MD (US) (1988)
- Fort Washington, MD (US) (1983 - 1994)
Company Filing History:
2 out of 2,202 
1 out of 2,546 
1 out of 1,217 
Years Active: 1976-1994
Title: Grace L Picciolo: Innovator in Biomedical Monitoring
Introduction
Grace L Picciolo is a distinguished inventor based in Fort Washington, MD (US). She has made significant contributions to the field of biomedical monitoring, holding a total of 7 patents. Her work focuses on innovative methods for assessing oxidative products and immunological responses, which are crucial for the development of medical devices.
Latest Patents
One of her latest patents is titled "Real-time monitoring of oxidative products from in vitro." This invention presents a chemiluminescence method for continuously monitoring the generation of oxidative products, such as hydrogen peroxide and superoxide, from in vitro cell-biomaterial interactions. The method utilizes various cell lines, including Human Leukemic cells (HL-60) and primary human cells, to predict the functional lifetime of biomaterials used in implanted medical devices. Additionally, it aids in determining the activation level of biological cells, which is essential for assessing the inflammatory response and biocompatibility of materials.
Another notable patent is the "Device for quantitative endpoint determination in immunofluorescence." This invention provides a process for quantifying Toxoplasma gondii and Treponema pallidum antibody titers in biological samples through immunofluorescent photometric microscopy. This advancement enhances the accuracy of immunological assessments in clinical settings.
Career Highlights
Throughout her career, Grace has worked with various organizations, including the United States of America as represented by the Secretary of Health and Human Services. Her innovative approaches have significantly impacted the biomedical field, particularly in the development of diagnostic and monitoring devices.
Collaborations
Grace has collaborated with notable individuals in her field, including Emmett W Chappelle and David S Kaplan. These partnerships have fostered advancements in her research and contributed to her success as an inventor.
Conclusion
Grace L Picciolo's contributions to biomedical monitoring through her innovative patents demonstrate her commitment to improving medical technology. Her work not only enhances our understanding of cell interactions with biomaterials but also paves the way for safer and more effective medical devices.