Location History:
- Indianapolis, IN (US) (1978 - 1979)
- Mooresville, IN (US) (1980)
Company Filing History:
Years Active: 1978-1980
Title: Gloria C. Paschal: Innovator in Pharmaceutical Chemistry
Introduction
Gloria C. Paschal is a distinguished inventor based in Indianapolis, IN (US). She has made significant contributions to the field of pharmaceutical chemistry, holding a total of 4 patents. Her work focuses on innovative processes that enhance the efficacy of pharmaceutical compounds.
Latest Patents
Among her latest patents is the synthesis of Vindesine. This process involves converting 4-desacetyl VLB C-3 carboxhydrazide to the corresponding azide using a nitrite such as n-butyl nitrite in THF. The azide is then reacted with triphenylphosphine to yield an intermediate acyl iminophosphorane, which is decomposed with acid to produce high-purity Vindesine in good yield. Another notable patent is the process of producing 5'-hydroxyleurosine and related compounds. These compounds are useful in inhibiting the growth of experimental tumors, showcasing her commitment to advancing cancer treatment.
Career Highlights
Gloria C. Paschal is currently employed at Eli Lilly and Company, a leading pharmaceutical firm known for its innovative research and development. Her work at Eli Lilly has allowed her to contribute to groundbreaking advancements in drug development and therapeutic solutions.
Collaborations
Throughout her career, Gloria has collaborated with esteemed colleagues, including Gerald L. Thompson and Robert A. Conrad. These partnerships have fostered a collaborative environment that enhances the innovation process and leads to successful outcomes in their research endeavors.
Conclusion
Gloria C. Paschal's contributions to pharmaceutical chemistry through her patents and collaborations highlight her role as a key innovator in the field. Her work continues to impact the development of effective treatments, particularly in oncology.