Company Filing History:
Years Active: 2022
Title: The Innovations of Gianluca Petris in High-Fidelity Genome Editing
Introduction
Gianluca Petris, an inventive mind hailing from Sauris, Italy, has made significant strides in the field of genome editing. With a keen focus on improving the precision of the CRISPR/Cas9 technology, he holds one patent that showcases his groundbreaking work in high-fidelity CAS9 variants.
Latest Patents
His notable patent is titled "High-fidelity CAS9 variants and applications thereof." This invention addresses the challenges posed by non-specific genomic cleavages commonly associated with SpCas9. By employing a yeast-based assay, Petris has developed a method to evaluate the on- and off-target activity towards engineered genomic targets simultaneously. The random mutagenesis of the Red-II domain led to the identification of SpCas9 variant hits that exhibit enhanced on/off ratios. The most effective nuclease, named evoCas9, was created by amalgamating the identified mutations into one variant. Compared to previously reported rationally designed variants, evoCas9 demonstrates a remarkable improvement in fidelity.
Career Highlights
Gianluca Petris is affiliated with the Università Degli Studi di Trento, where he contributes to research in the field of genetic editing. His expertise and innovative approach have played a crucial role in advancing the efficacy of gene-editing tools.
Collaborations
Petris collaborates with notable colleagues in his field, including Anna Cereseto and Antonio Casini. Their combined efforts enhance the research output at their institution, driving forward the frontiers of genome editing and biotechnology.
Conclusion
In summary, Gianluca Petris stands out as an impactful inventor in genome editing. His work on high-fidelity CAS9 variants significantly contributes to the field, providing researchers with more precise tools for genomic modifications. As he continues to innovate, the advancements resulting from his inventions promise to shape the future of genetic research and applications.