Company Filing History:
Years Active: 2013
Title: Innovations of Gerald Linette in Immunology
Introduction
Gerald Linette is a notable inventor based in St. Louis, MO (US). He has made significant contributions to the field of immunology, particularly in the development of innovative methods for expanding antigen-specific T cell populations. His work has implications for cancer therapy and vaccine development.
Latest Patents
Gerald Linette holds a patent for "Single chain trimers and uses therefor." This patent describes single chain trimer (SCT) molecules that comprise an MHC antigen peptide sequence, a β-microglobulin sequence, and a full-length MHC class I heavy chain sequence, all joined by linker sequences. The patent further details nucleic acids encoding these single chain trimers. The methods outlined in the patent can achieve a remarkable 10,000-100,000 fold expansion of antigen-specific CD8+ T cells within approximately 28 days, yielding over 1 billion antigen-specific CD8+ T cells from a single donor.
Career Highlights
Gerald Linette is affiliated with Washington University, where he continues to advance research in immunotherapy. His innovative approaches have garnered attention in the scientific community, contributing to the understanding of T cell biology and its applications in medicine.
Collaborations
He has collaborated with notable colleagues such as Ted H Hansen and Michelle Becker-Hapak, enhancing the research output and fostering a collaborative environment in their field.
Conclusion
Gerald Linette's work exemplifies the intersection of innovation and practical application in immunology. His contributions are paving the way for advancements in T cell therapies and have the potential to impact patient care significantly.