George P Smith

Title: Innovations by George P. Smith in Peptide Research

Introduction

George P. Smith is an accomplished inventor based in Columbia, MO, recognized for his innovative contributions to the field of peptide research. With a total of two patents to his name, he has made significant strides in identifying and purifying peptides that have potential applications in pharmaceuticals and other bioactive compounds.

Latest Patents

Smith's most recent patents focus on two groundbreaking methods. The first patent, “Phage display selection of antifungal peptides,” presents a method for identifying peptides that can attach to fungal surfaces and influence their development. This patent includes detailed processes for creating compositions involving peptides, as well as isolated polynucleotides, vectors, expression cassettes, and transformed cells designed for expressing these peptides.

His second patent, titled “Method of obtaining small conformationally rigid conopeptides,” outlines a sophisticated approach for separating and purifying small, rigidly structured peptides akin to conotoxins. This method involves forming a library of conoeffectors, which are bacteriophages displaying potential conopeptide sequences. Through a series of screenings for binding affinity to target proteins, this innovative method enables the generation of diverse small peptides rich in disulfide bonds, serving as candidates for pharmaceutical or pesticidal applications.

Career Highlights

Throughout his career, George P. Smith has been associated with esteemed institutions such as the University of Missouri and the University of Utah Research Foundation. His work has greatly advanced the understanding of peptide functionality and applications in various fields.

Collaborations

Smith has collaborated with respected colleagues, including Baldomero M. Olivera and David R. Hillyard. These partnerships have furthered research efforts and have contributed to the successful development of his patented technologies.

Conclusion

George P. Smith stands out as a significant innovator in the realm of peptide research. His inventive methods pave the way for a deeper understanding of peptide interactions and potential therapeutic applications, positioning him as a key player in the evolution of bioactive compounds.