George L Spitalny

Title: The Innovative Contributions of George L. Spitalny

Introduction

George L. Spitalny is a notable inventor based in Cheshire, Connecticut. He has made significant contributions to the field of molecular biology through his innovative patent. His work focuses on enhancing targeted delivery systems for polynucleotides, which has important implications for therapeutic applications.

Latest Patents

George L. Spitalny holds a patent for the use of a bacterial component to enhance the targeted delivery of polynucleotides. This patent describes an improved soluble molecular complex designed to target specific cells. The complex consists of a polynucleotide, a carrier made up of a polynucleotide binding agent and a cell-specific binding agent, and a bacterial component that lyses the endosome to release the polynucleotide into the cytoplasm. In his preferred embodiment, the polynucleotide binding agent is polylysine, the cell-specific binding agent is an asialoglycoprotein, and the bacterial component is listeriolysin O. This invention can be utilized therapeutically to deliver genes and antisense polynucleotides to specific cells in vivo.

Career Highlights

Throughout his career, George L. Spitalny has worked with various organizations, including the University of Connecticut and Targetech, Inc., a wholly owned subsidiary of the Immune Response. His experience in these institutions has contributed to his expertise in molecular delivery systems.

Collaborations

George L. Spitalny has collaborated with notable individuals in his field, including George Y. Wu and Catherine H. Wu. These collaborations have likely enriched his research and development efforts.

Conclusion

George L. Spitalny's innovative work in the field of molecular biology, particularly in the targeted delivery of polynucleotides, showcases his significant contributions to science and medicine. His patent reflects a promising advancement in therapeutic applications, highlighting the importance of his research.