Company Filing History:
Years Active: 1992-1996
Title: Innovations of George Boguslawski
Introduction
George Boguslawski is an accomplished inventor based in South Bend, Indiana. He holds two patents that focus on advancements in protease stability, particularly in the context of detergent applications. His work has significant implications for the detergent industry, enhancing the effectiveness of cleaning products.
Latest Patents
Boguslawski's latest patents include "Proteases of altered stability to autolytic degradation" and "Bleach stable enzymes." The first patent addresses the susceptibility of proteases to autolytic degradation. The method outlined in this invention identifies susceptible autolysis sites that can be cleaved to produce discrete fragments. By chemically modifying the amino acids at or near the cleavage site, or altering the DNA sequence encoding these amino acids, it is possible to create autolysis-stable proteases. This invention is particularly relevant for alkaline proteases, which are produced in large quantities and utilized as detergent additives. The second patent focuses on identifying cleavage sites of enzymes in the presence of hypochlorite, specifically at tryptophan residues. By modifying or deleting tryptophan, a more stable enzyme can be produced, retaining its activity in bleach-containing environments. This invention also targets alkaline proteases, which are valuable in detergent formulations.
Career Highlights
George Boguslawski is currently employed at Solvay Enzymes, Inc., where he continues to contribute to the field of enzymatic research and development. His innovative approaches to enzyme stability have positioned him as a key figure in the industry.
Collaborations
Throughout his career, Boguslawski has collaborated with notable colleagues, including John W. Shultz and Josephine Grosch. These partnerships have fostered a collaborative environment that enhances the development of innovative solutions in enzymatic applications.
Conclusion
George Boguslawski's contributions to the field of protease stability have the potential to revolutionize the detergent industry. His patents reflect a commitment to innovation and a deep understanding of enzymatic processes. His work continues to influence the development of more effective cleaning products.