Company Filing History:
Years Active: 1983-2005
Title: Frank H Ruddle: Innovator in Genetic Research
Introduction
Frank H Ruddle is a prominent inventor based in New Haven, CT, known for his significant contributions to genetic research. He holds a total of seven patents, showcasing his innovative approach to solving complex biological problems. His work has had a profound impact on the field of genetics, particularly in the areas of DNA manipulation and analysis.
Latest Patents
Among his latest patents is the "Efficient cis-element discovery method using multiple sequence comparisons based on evolutionary relationships." This method allows for the efficient searching of non-coding DNA to identify known control elements. By selecting DNA sequences from species with a significant genetic distance, researchers can calculate total substitutions using pair-wise genetic distances, enhancing the understanding of evolutionary relationships.
Another notable patent is the "Yeast-Bacteria shuttle vector." This invention addresses the need for manipulating large genomic regions, which is crucial for functional gene analysis. The shuttle vector enables the cloning of large DNA regions through homologous recombination. Its unique feature is the inclusion of a bacterial replication origin, which facilitates the isolation and maintenance of large DNA fragments in both bacteria and yeast.
Career Highlights
Frank H Ruddle has had a distinguished career, working with esteemed institutions such as Yale University and Genaissance Pharmaceuticals, Inc. His experience in these organizations has allowed him to collaborate with leading experts in the field and contribute to groundbreaking research.
Collaborations
Throughout his career, Ruddle has worked alongside notable colleagues, including M Suzanne Bradshaw and Jacques A Bollekens. These collaborations have further enriched his research and innovation in genetic studies.
Conclusion
Frank H Ruddle's contributions to genetic research through his patents and collaborations highlight his role as a leading inventor in the field. His innovative methods and tools continue to advance the understanding of genetics and its applications.