Location History:
- Mtl., CA (1997)
- Que, CA (1999)
Company Filing History:
Years Active: 1997-1999
Title: **Francoise Blain: Innovator in Heparinase Research**
Introduction
Francoise Blain is a notable inventor based in Montreal, Canada, recognized for her significant contributions to the field of biochemistry and enzymatic research. With a total of two patents to her name, her work primarily focuses on the isolation and characterization of enzymes responsible for the degradation of heparin and heparan sulfate.
Latest Patents
Francoise Blain's latest patents include critical advancements in nucleic acid sequences and expression systems for heparinase II. The inventions detail the isolation and sequence of genes from *Flavobacterium heparinum*, which encode heparin and heparan sulfate degrading enzymes, specifically heparinase II and heparinase III (EC 4.2.2.8).
The patents further elaborate on methodologies for expressing these heparinases, utilizing a modified ribosome binding region from promoters derived from glycosaminoglycan lyase genes of *F. heparinum*. Moreover, her work outlines a comprehensive multi-step protein purification method that includes cell disruption, cation exchange chromatography, affinity chromatography, and hydroxylapatite chromatography. Additionally, the patents describe the development of antibodies against a post-translational modification moiety common in *Flavobacterium heparinum* proteins, along with methods for obtaining antibodies specific to these modifications and the amino acid sequences of heparinases I, II, and III.
Career Highlights
Francoise Blain is currently associated with Ibex Technologies Ltd., a company that specializes in innovative solutions in biotechnology. Her career is marked by her dedication to advancing our understanding of heparin-degrading enzymes and their applications in various therapeutic contexts.
Collaborations
Throughout her career, Francoise has collaborated with esteemed colleagues, including Hongsheng Su and Clark Bennett. These collaborations have enhanced the research and development aspects of her inventions, fostering a productive work environment conducive to scientific innovation.
Conclusion
In conclusion, Francoise Blain's contributions to the field of biochemistry through her patented innovations exemplify the vital role inventors play in advancing scientific research. Her work not only addresses fundamental biochemical challenges but also opens new avenues for therapeutic applications, reflecting her commitment to innovation and collaboration in science.