Company Filing History:
Years Active: 2016-2021
Title: Ernesto Torres de Azevedo Marques: A Pioneer in DNA Vaccine Research
Introduction
Ernesto Torres de Azevedo Marques is an innovative inventor based in Pernambuco, Brazil, renowned for his contributions in the field of vaccine development. With a total of three patents to his name, his latest work focuses on groundbreaking advancements in DNA vaccines, specifically targeting the yellow fever virus. His research promises to enhance the efficacy of vaccinations and improve public health outcomes.
Latest Patents
Marques’ most notable invention is a revolutionary DNA vaccine against the yellow fever virus. The invention elucidates the development of DNA vaccines that encode specific viral sequences, aimed at inducing robust immune responses. Notably, the vaccines utilize the sequence coding for the yellow fever virus envelope protein (p/YFE). Additionally, the wild p/YFE construct is complemented by a fusion with the human lysosome-associated membrane protein (h-LAMP), resulting in the innovative construct termed pL/YFE. This new construct has exhibited promising results, capable of inducing T-cell responses similar to the established 17DD vaccine, while also generating satisfactory levels of neutralizing antibodies. Remarkably, in testing, 100% of mice inoculated with the pL/YFE vector survived an intracerebral challenge with the yellow fever virus, underscoring the potential of his vaccine approach.
Career Highlights
Ernesto has had an impactful career working with prestigious organizations. Notably, he has collaborated with Fundação Oswaldo Cruz, a renowned research institution in Brazil, as well as The Johns Hopkins University, recognized globally for its contributions to biomedical research. His work in these institutions has undoubtedly enriched his expertise in the fields of virology and immunology.
Collaborations
Throughout his career, Marques has worked alongside esteemed colleagues such as Rafael Dhalia and Romulo Maciel Filho. These collaborations have fostered an environment of innovation, allowing for the exchange of ideas and techniques vital in the advancement of vaccine research.
Conclusion
Ernesto Torres de Azevedo Marques stands as a significant figure in the realm of vaccine development, with his latest inventions marking significant strides in combating viral diseases. His dedication to advancing public health through innovative research continues to inspire future generations of inventors and scientists. As the world faces ongoing challenges from infectious diseases, contributions like those from Marques are essential in creating effective solutions.