Elizabeth M Boon

Title: Elizabeth M. Boon: Pioneering Innovations in Electrochemical Biosensing

Introduction

Elizabeth M. Boon is a distinguished inventor based in Pasadena, California, known for her significant contributions to the field of electrochemical sensing technologies. With a total of two patents to her name, her innovative work is making a considerable impact on biosensing capabilities, particularly in the detection of genetic mutations and other DNA-related issues.

Latest Patents

Boon's latest patents focus on the development of an electrochemical sensor utilizing intercalative, redox-active moieties. Her work outlines compositions and methods for the electrochemical detection and localization of genetic point mutations, common DNA lesions, and various base-stacking perturbations within oligonucleotide duplexes that are adsorbed onto electrodes. This technology employs an intercalative, redox-active moiety, such as an intercalator or a nucleic acid-binding protein, which is either adhered to or cross-linked with immobilized DNA duplexes at varying distances from an electrode. The electrochemical probing of this setup can reveal interruptions in DNA-mediated electron transfer due to base-stacking disturbances. This pioneering method facilitates a better understanding of genetic variations by observing changes in electrical current, charge, or potential.

Career Highlights

Elizabeth M. Boon is affiliated with the California Institute of Technology, an institution renowned for its rigorous scientific research and innovation. Her work at Caltech continues to inspire advancements in the fields of genetics and biosensing, positioning her as a leader in scientific innovation.

Collaborations

Throughout her career, Boon has collaborated with esteemed colleagues such as Jacqueline K. Barton and Shana O. Kelley. Their collective efforts not only enhance the quality and reach of their research but also contribute to the collaborative spirit essential in advancing scientific discovery.

Conclusion

In summary, Elizabeth M. Boon has established herself as a key figure in the innovation of electrochemical biosensing technologies. Her groundbreaking patents and collaborative efforts in the field continue to push the boundaries of what is possible in genetic detection and analysis, marking her as an influential inventor in the landscape of modern science.