Edward A Kesicki

Title: The Innovative Contributions of Edward A. Kesicki

Introduction

Edward A. Kesicki is a notable inventor based in San Pedro, California. He has made significant contributions to the field of protein micro sequencing. His innovative methods have advanced the capabilities of peptide sequencing, particularly in the analysis of polypeptides and proteins.

Latest Patents

Kesicki holds a patent for a method of thioacylation peptide sequencing. This method involves the reaction of the N-terminal amino acid of a polypeptide with an excess of a thioacylating reagent. After ensuring quantitative coupling and removing excess reagent, the derivatized polypeptide undergoes cleavage by acid. This process yields a 2-substituted-5(4H)-thiazolinone. Following the removal of excess acid, the thiazolinone is reacted with a fluorescent or enhanced ultraviolet absorbance reagent. This reaction allows for the detection of very small amounts of protein, making it a valuable tool in protein sequencing.

Career Highlights

Kesicki is associated with Bio-Affinity Systems, Inc., where he continues to develop innovative solutions in the field of biochemistry. His work has been instrumental in enhancing the methods used for protein analysis.

Collaborations

Throughout his career, Kesicki has collaborated with notable colleagues, including Mark L. Stolowitz and Vyas M. Dixit. These collaborations have contributed to the advancement of research in protein sequencing and related fields.

Conclusion

Edward A. Kesicki's contributions to the field of protein micro sequencing demonstrate his innovative spirit and dedication to scientific advancement. His patented methods provide essential tools for researchers in biochemistry and molecular biology.