Edward A Botchwey, Iii

Title: Innovations by Edward A Botchwey, III

Introduction

Edward A Botchwey, III is a notable inventor based in Charlottesville, VA. He has made significant contributions to the fields of oxygen sensing and tissue engineering, holding a total of three patents. His work focuses on developing advanced materials and methods that enhance medical applications.

Latest Patents

One of his latest patents is titled "Compositions and methods for making and using oxygen sensing nanofibers and scaffolds." This invention addresses the need for scaffold-based oxygen concentration monitoring by creating a single-component, self-referenced oxygen sensor made into nanofibers. The electrospinning process parameters were optimized to produce a biomaterial scaffold with specific morphological features. The invention calculates the ratio of an oxygen-sensitive phosphorescence signal to an oxygen-insensitive fluorescence signal at each image pixel to determine an oxygenation value. The results indicate that the fibers are responsive to dissolved oxygen concentrations less than 15 parts per million.

Another significant patent is "Compositions and methods for tissue engineering and cell-based therapies." This application reveals strategies to recruit and mobilize stem cells using S1P receptor selective agonists and antagonists, as well as regulators of chemokine receptors. In an in vivo ischemic model, S1P/S1P activation with FTY720 impeded inflammatory cell infiltration and recruited endothelial progenitor cells (EPCs), which have the potential to enhance microvascular remodeling