Company Filing History:
Years Active: 2007-2016
Title: Innovations of Edgardo Farinas in Cytochrome P450 Research
Introduction
Edgardo Farinas, an accomplished inventor based in Pasadena, California, has made significant contributions to the field of biochemistry through his innovative work on cytochrome P450 enzymes. With a total of six patents to his name, Farinas continues to push the boundaries of enzyme engineering and its applications.
Latest Patents
One of Farinas's latest patents focuses on cytochrome P450 oxygenases, providing nucleic acids that encode variants of cytochrome P450. These variants exhibit enhanced alkane-oxidation and alkene-oxidation capabilities, as well as increased resistance to organic solvents compared to the wild-type cytochrome P450 enzymes. Notably, one preferred wild-type enzyme is cytochrome P450 BM-3. The improved variants include amino acid substitutions such as V78A, H236Q, and E252G, which enhance the enzyme's ability to hydroxylate alkanes and epoxidate alkenes, particularly for compounds with fewer than 8 carbons. Additionally, these variants demonstrate superior hydroxylation activity in co-solvent environments, with specific substitutions such as T235A, R471A, E494K, and S1024E contributing to their enhanced performance.
Career Highlights
Edgardo Farinas is affiliated with the California Institute of Technology, where he collaborates with leading scientists in the field. His extensive research and practical applications have reinforced his status as a key figure in enzymology. Farinas's contributions to the understanding and engineering of cytochrome P450 enzymes stand out in the scientific community.
Collaborations
Throughout his career, Farinas has had the privilege of collaborating with renowned researchers such as Frances H Arnold and Ulrich Schwaneberg. These partnerships have facilitated knowledge exchange and have further propelled innovations in enzyme research.
Conclusion
Edgardo Farinas exemplifies the spirit of innovation in the science of enzyme technology. His work with cytochrome P450 variants not only highlights his ingenuity but also promises advancements in various applications, including industrial biocatalysis and pharmaceuticals. As he continues his research at the California Institute of Technology, the scientific community eagerly anticipates his future contributions.