Diane Thibeault

Title: Diane Thibeault: Innovator in Hepatitis C Research

Introduction

Diane Thibeault is a prominent inventor based in Laval, Canada. She has made significant contributions to the field of hepatitis C research, holding 2 patents that focus on innovative assays and methods for detecting and producing active forms of the NS2/3 protease.

Latest Patents

Her latest patents include a novel assay for Hepatitis C virus NS2/3 activity detection. This invention provides a method for detecting the NS3 cleavage product in the presence of uncleaved NS2/3. It allows for the discrimination of the resulting NS3 protease product from the uncleaved protein without the need for physical separation. The assay utilizes specific reaction conditions to create a 'signal window' that facilitates the measurement of NS3 protease activity. Additionally, she has developed a method for producing a purified active form of the HCV NS2/3 protease. This method involves purifying the protease from inclusion bodies and refolding it in the presence of a reducing agent and lauryldiethylamine oxide. The invention also includes a method for activating the refolded protease, enabling the screening of small molecules and ligands as potential inhibitors.

Career Highlights

Diane has worked with notable companies such as Boehringer Ingelheim (Canada) Ltd. and Boehringer Ingelheim International GmbH. Her work in these organizations has contributed to advancements in therapeutic agents against hepatitis C.

Collaborations

Throughout her career, Diane has collaborated with esteemed colleagues, including Roger Maurice and Daniel Lamarre. These partnerships have further enhanced her research and innovation in the field.

Conclusion

Diane Thibeault's contributions to hepatitis C research through her patents and collaborations highlight her role as an influential inventor. Her innovative approaches continue to pave the way for advancements in therapeutic solutions against this viral infection.