Company Filing History:
Years Active: 2007-2009
Title: Dhaval Gosalia: Innovator in Mass Spectrometry
Introduction
Dhaval Gosalia is a prominent inventor based in Philadelphia, PA (US). He has made significant contributions to the field of mass spectrometry, particularly in the development of methods and devices for peptide and protein microassays. With a total of 2 patents, his work has advanced the capabilities of biological sample analysis.
Latest Patents
Gosalia's latest patents focus on a method and devices for running reactions on a target plate for MALDI mass spectrometry. This innovative approach allows for a wide variety of chromogenic or fluorogenic peptide or protein substrates to be individually suspended or dissolved in a hydrophilic carrier. Aliquots of each substrate are deposited in an array or microarray of reaction loci, or 'dots.' Each dot serves as an individual reaction vessel containing the peptide or protein of interest, to which a biological sample may be applied for assay purposes. The application of the sample is achieved through various focused sample application techniques, including aerosolizing or misting, ensuring no fluid channels are created between the dots to prevent cross-contamination. Additionally, the invention provides methods for transferring samples from an electrophoretic gel to a target plate for subsequent MALDI MS analysis. Chemical reactions can be conducted directly on the target plate, with the reaction products prepared for MALDI MS analysis by drying and aerosol deposition of matrix material, eliminating the need for salt removal and additional processing steps.
Career Highlights
Gosalia is affiliated with the University of Pennsylvania, where he continues to contribute to research and innovation in mass spectrometry. His work has garnered attention for its practical applications in biological assays and chemical analysis.
Collaborations
One of his notable collaborators is Scott L Diamond, with whom he has worked on various projects related to mass spectrometry and its applications.
Conclusion
Dhaval Gosalia's contributions to the field of mass spectrometry through his innovative patents and research at the University of Pennsylvania highlight his role as a key inventor in advancing scientific methodologies. His work continues to impact the way biological samples are analyzed and understood.