Denis Bouvier

Title: Denis Bouvier: Innovator in Viral Research and Endonuclease Activity

Introduction

Denis Bouvier, located in Meylan, France, is a notable inventor recognized for his contribution to the field of viral research. His innovative spirit has been captured in a groundbreaking patent that addresses a crucial aspect of viral mechanisms, particularly within viruses belonging to the Orthomyxoviridae family.

Latest Patents

Denis Bouvier holds a significant patent titled "Polypeptide fragments comprising endonuclease activity and their use." This invention focuses on polypeptide fragments that include an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase, along with its variants. These fragments possess endonuclease activity, which is pivotal in understanding viral replication and potential intervention methods. The patent also includes the development of crystals of these polypeptide fragments, suitable for structure determination via X-ray crystallography. Furthermore, it outlines computational methods for screening and designing compounds that could modulate or inhibit the endonucleolytically active site within the fragments. Importantly, this invention delineates methods for identifying compounds that bind to the PA polypeptide fragments and inhibit their endonucleolytic activity, especially in high throughput settings. This work ultimately contributes to the development of pharmaceutical compositions aimed at treating diseases caused by viral infections from the Orthomyxoviridae family.

Career Highlights

Throughout his career, Denis Bouvier has been associated with prominent research institutions, including the European Molecular Biology Laboratory and the Centre National de la Recherche Scientifique. His experience in these esteemed organizations has played a pivotal role in shaping his research and inventions, helping to advance our understanding of viral enzymes and their potential therapeutic targets.

Collaborations

Denis has collaborated with notable colleagues such as Thibaut Crepin and Rob Ruigrok. These partnerships have fostered a productive research environment, enabling meaningful advancements in their shared scientific interests.

Conclusion

Denis Bouvier exemplifies the role of an innovator in the realm of virology, with his patented research poised to impact the treatment of viral infections. His collaborative endeavors and contributions to the scientific community illustrate a dedication to addressing significant health challenges through innovative science.