Title: Innovations by David Y-W Lee in Non-Invasive Detection of Tissue Hypoxia.
Introduction
David Y-W Lee is an innovative inventor based in the United States. He has made significant contributions to the field of medical imaging and detection technologies. His work focuses on the development of methods for the non-invasive detection of tissue hypoxia, which is crucial for diagnosing various medical conditions.
Latest Patents
David Y-W Lee holds a notable patent titled "Weakly Basic 2-Nitroimidazoles For The Non-Invasive Detection Of Tissue Hypoxia." This invention incorporates weakly basic substituents, such as pyrrolidine, piperidine, piperazine, and azapane moieties in halogenated 2-nitromidazoles. This approach represents a major improvement over prior art for the non-invasive detection of cellular hypoxia in both normal and malignant tissues. The invention utilizes advanced imaging techniques, including [18F] positron emission tomography, [19F] magnetic resonance spectroscopy, and [19F] magnetic resonance imaging.
The improvements over prior art compounds are significant. Firstly, salts of weakly basic reagents are highly water-soluble, facilitating administration. Secondly, unreacted reagents are rapidly cleared from systemic circulation, thereby decreasing background noise. Thirdly, reagents with weakly basic substituents are concentrated in tissue approximately three-fold above plasma levels, increasing binding intensity and enhancing signal detection. Fourthly, conjugate bases of weakly basic reagents have intermediate octanol-water partition coefficients, allowing for better penetration into all tissues, including the brain. Fifthly, cellular adducts of reagents containing weakly basic substituents are more stable than those of prior art. Lastly, these reagents are effective for detecting transient hypoxia in solid tissue.
Career Highlights
David Y-W Lee is currently associated with Natural Pharmacia International, Inc. His work has been pivotal in advancing non-invasive medical imaging techniques. Despite having no patents listed, his contributions to the field are noteworthy and impactful.
Collaborations
David has collaborated with esteemed colleagues, including James A Raleigh and Xiaoshen Ji. Their combined expertise has furthered the development of innovative solutions in medical imaging.
Conclusion
David Y-W Lee's work in the field of non-invasive detection of tissue hypoxia showcases his innovative spirit and dedication to advancing