Company Filing History:
1 out of 92 
1 out of 9 Years Active: 1996-1999
Title: David Robert Patterson: Innovator in Nucleic Acid Amplification
Introduction
David Robert Patterson is a notable inventor based in Rochester, NY (US). He has made significant contributions to the field of nucleic acid amplification, holding 2 patents that enhance the efficiency and sensitivity of PCR (Polymerase Chain Reaction) methods.
Latest Patents
One of his latest patents is titled "Use of exonuclease and/or glycosylase as supplements to anti-polymerase." This invention provides admixtures and methods for PCR amplification of a target nucleic acid, where amplification efficiency is increased by including an antibody specific for a polymerization agent and at least one of an exonuclease and a glycosylase in the PCR reaction mix. Additionally, he holds a patent for a "Homogeneous method for assay of double-stranded nucleic acids using" a highly sensitive homogeneous assay that allows for quantitative detection of amplified nucleic acids. This detection is achieved during or after amplification with a high-affinity fluorescent dye from the class of unsymmetrical cyanine dyes, which have at least two positive charges and a binding constant (K.sub.b) within the range of about 1.times.10.sup.4 to about 5.times.10.sup.5 (molar.sup.-1). The reagents used for the assay can be contained in a kit designed for amplification, such as by polymerase chain reaction.
Career Highlights
David has worked with prominent companies in the diagnostics field, including Johnson & Johnson Clinical Diagnostics, Inc. and Clinical Diagnostic Systems, Inc. His work has significantly impacted the development of diagnostic tools and methods.
Collaborations
Throughout his career, David has collaborated with various professionals, including John W. Sutherland, enhancing the innovation process in his field.
Conclusion
David Robert Patterson is a distinguished inventor whose work in nucleic acid amplification has led to advancements in PCR technology. His contributions continue to influence the field of molecular diagnostics.