David Repaske

Title: The Innovations of David Repaske

Introduction

David Repaske is an accomplished inventor based in Loveland, Ohio. He has made significant contributions to the field of neuroscience through his innovative research and patents. His work primarily focuses on intracellular signaling pathways, particularly those involving phosphodiesterase 1B (PDE1B).

Latest Patents

David Repaske holds a patent titled "Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain." This invention provides methods and compositions for modulating the activity of PDE1B in intracellular signaling pathways, including dopamine D1 intracellular signaling pathways. The patent outlines methods for modulating the activities of intracellular signaling molecules, such as DARPP-32 and GluR1 AMPA receptor, through the modulation of PDE1B. Additionally, it includes pharmaceutical compositions and methods for screening compounds that can modulate PDE1B activity. The invention also offers methods for treating or alleviating symptoms of disorders related to PDE1B or dopamine D1 receptor intracellular signaling pathways by administering a modulator of PDE1B.

Career Highlights

Throughout his career, David Repaske has worked with prestigious institutions, including The Rockefeller University and Children's Hospital Medical Center. His research has contributed to a deeper understanding of the mechanisms underlying various neurological disorders.

Collaborations

David has collaborated with notable scientists, including Paul Greengard and Gretchen L. Snyder. These collaborations have further enriched his research and expanded the impact of his inventions.

Conclusion

David Repaske's innovative work in the field of neuroscience, particularly through his patent on PDE1B, showcases his dedication to advancing our understanding of intracellular signaling pathways. His contributions continue to influence research and potential treatments for related disorders.