Company Filing History:
Years Active: 2020-2025
Title: Innovations by David Plas in Cancer Diagnostics and Treatment
Introduction
David Plas is an accomplished inventor based in Cincinnati, OH (US). He has made significant contributions to the field of cancer diagnostics and treatment, holding 2 patents that focus on innovative methods for addressing clear cell renal cell carcinoma.
Latest Patents
One of his latest patents involves diagnostic tools and treatments for clear cell renal cell carcinoma. This method provides a way to diagnose the likelihood of recurrence of the disease by detecting gene expression signatures in kidney tumor tissue samples. Specifically, it assesses mitochondrial electron transport chain subunits, mitochondrial ribosomal proteins, and major histocompatibility complex class II (MHC-II) proteins. If certain gene expression signatures are present, it indicates an elevated risk of recurrence. Additionally, this method incorporates the use of copper levels to further diagnose the likelihood of recurrence.
Another notable patent by David Plas focuses on targeting metabolic adaptive responses to chemotherapy. This method describes the administration of compounds that inhibit S6K1, mTORC1, or their pathway components, in conjunction with inhibitors of PPARα, PPARδ, or PGC1α. The compounds used in this method include rapamycin, everolimus, temsirolimus, and imatinib, among others.
Career Highlights
David Plas is affiliated with the University of Cincinnati, where he continues to advance research in cancer treatment and diagnostics. His work has garnered attention for its potential to improve patient outcomes in oncology.
Collaborations
He collaborates with esteemed colleagues, including Maria Franciszka Czyzyk-Krzeska and Julio Alberto Landero Figueroa, contributing to a dynamic research environment focused on innovative cancer therapies.
Conclusion
David Plas's contributions to cancer diagnostics and treatment exemplify the impact of innovative research in medicine. His patents reflect a commitment to improving the lives of patients facing serious health challenges.