Company Filing History:
Years Active: 1994-1997
Title: David Cunningham: Innovator in Platelet Glycoprotein Research
Introduction
David Cunningham is a notable inventor based in Syracuse, NY (US). He has made significant contributions to the field of biotechnology, particularly in the study of platelet glycoproteins. With a total of 5 patents to his name, Cunningham's work has advanced our understanding of blood coagulation and related disorders.
Latest Patents
Cunningham's latest patents focus on mutations in the gene encoding the alpha chain of platelet glycoprotein. The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha, which have a mutation that enhances the polypeptide's reactivity with von Willebrand factor. Notably, the mutation occurs in the hinge region of GP Ib.alpha., specifically the substitution of valine for glycine at residue 233. These mutations result in a change in the three-dimensional structure of the mutant polypeptide from a beta bend conformation to an alpha helix formation. Additionally, they create an amphipathic region within the mutant polypeptide. The patents also include DNA encoding the mutant polypeptides, expression systems for their production, and methods and compositions utilizing the mutant polypeptides and complementary DNA oligomers.
Career Highlights
Cunningham is affiliated with the State University of New York, where he conducts his research and development. His work has been instrumental in advancing the field of platelet glycoprotein research, contributing to both academic knowledge and practical applications in medicine.
Collaborations
Cunningham has collaborated with notable colleagues, including Jonathan L Miller and Vicki A Lyle. These partnerships have fostered a collaborative environment that enhances the research output and innovation in their field.
Conclusion
David Cunningham's contributions to the field of platelet glycoprotein research exemplify the impact of innovative thinking in biotechnology. His patents and collaborative efforts continue to pave the way for advancements in medical science.