David Bramhill

Title: The Innovative Contributions of David Bramhill

Introduction

David Bramhill is a notable inventor based in Tucson, AZ (US). He has made significant contributions to the field of biotechnology, particularly in the development of fusion proteins and viable Gram-negative bacteria. With a total of 4 patents, his work has the potential to impact various applications in medicine and research.

Latest Patents

One of Bramhill's latest patents involves fusion proteins comprising immunoglobulin constant domain-derived scaffolds. This innovation features fusion proteins that include a base protein linked to a CH2 scaffold of IgG, derived from the macaque CH2 domain. These fusion proteins are designed to effectively bind to one or multiple targets and can be engineered to regulate effector functions as needed. They also exhibit increased serum half-life, solubility, stability, and protease resistance compared to the scaffolds or base proteins alone. Another significant patent focuses on viable Gram-negative bacteria with reduced proteolytic activity, which lack outer membrane agonists of TLR4/MD-2. This invention includes methods for creating and utilizing such bacteria, which may have applications in genetic research and therapeutic development.

Career Highlights

David Bramhill has been associated with Research Corporation Technologies, Inc., where he has been able to apply his innovative ideas and research skills. His work has contributed to advancements in biotechnology, particularly in the areas of protein engineering and microbial genetics.

Collaborations

Bramhill has collaborated with notable colleagues such as Uwe Mamat and Kurt R Gehlsen. These partnerships have likely enhanced the scope and impact of his research endeavors.

Conclusion

David Bramhill's contributions to the field of biotechnology through his patents and collaborative efforts highlight his role as an influential inventor. His work continues to pave the way for advancements in medical and research applications.