Company Filing History:
5 out of 1,179 
3 out of 86 
Years Active: 2015-2025
Title: Innovations by Inventor Dave Nichols
Introduction
Dave Nichols is a notable inventor based in Lexington, MA (US). He has made significant contributions to the field of genetic therapies, holding a total of 8 patents. His work primarily focuses on methods for treating rare genetic disorders.
Latest Patents
Among his latest patents is a method for the treatment of Hunter syndrome, which involves the use of iduronate-2-sulfatase. This invention provides improved methods for purifying the I2S protein produced recombinantly for enzyme replacement therapy. Notably, it is based on the discovery that recombinant I2S protein can be purified from unprocessed biological materials, such as I2S-containing cell culture medium, using a process that requires as few as four chromatography columns. Another significant patent involves the purification of arylsulfatase A (ASA) protein, which also focuses on enzyme replacement therapy. This invention highlights the ability to purify recombinant ASA protein from unprocessed biological materials using a similar process.
Career Highlights
Dave Nichols has worked with prominent companies in the pharmaceutical industry, including Takeda Pharmaceutical Company Limited and Shire Human Genetic Therapies, Inc. His experience in these organizations has contributed to his expertise in developing innovative therapies for genetic disorders.
Collaborations
Some of his notable coworkers include Igor Quinones-Garcia and Bee Lin Cheang. Their collaborative efforts have likely played a role in advancing the research and development of genetic therapies.
Conclusion
Dave Nichols is a distinguished inventor whose work in genetic therapies has led to significant advancements in the treatment of rare disorders. His innovative patents and collaborations reflect his commitment to improving patient outcomes through scientific research.