Company Filing History:
Years Active: 1998
Title: Dan O'Sullivan: Innovator in Bacteriophage-Triggered Cell Suicide Systems
Introduction
Dan O'Sullivan is a notable inventor based in Minneapolis, MN (US). He has made significant contributions to the field of biotechnology, particularly in the development of innovative systems that utilize bacteriophages for bacterial cell management. His work has implications for both research and practical applications in fermentation methods.
Latest Patents
O'Sullivan holds a patent for "Bacteriophage-triggered cell suicide systems and fermentation methods." This patent describes a bacterial cell containing a recombinant bacteriophage defense mechanism. The defense mechanism comprises a bacteriophage promoter operatively associated with heterologous DNA encoding a product lethal to the bacterial cell. The bacterial cell is susceptible to infection by a bacteriophage, and the promoter is activated upon the infection of said bacterial cell by that bacteriophage. Bacteria useful in carrying out the invention include both gram-negative and gram-positive bacteria, such as Lactococcus lactis and Escherichia coli. The heterologous DNA may encode an enzyme that degrades nucleic acid, such as the products of the LlaI restriction cassette or barnase. Recombinant DNAs useful for making the foregoing cells, cultures prepared from such cells, and fermentation methods carried out with such cells are also disclosed. O'Sullivan has 1 patent to his name.
Career Highlights
Dan O'Sullivan is affiliated with North Carolina State University, where he continues to engage in research and development in the field of biotechnology. His work has garnered attention for its innovative approach to utilizing bacteriophages in bacterial cell management.
Collaborations
O'Sullivan has collaborated with notable colleagues, including Todd Robert Klaenhammer and Mark A Conkling. These collaborations have contributed to the advancement of research in bacteriophage applications.
Conclusion
Dan O'Sullivan's innovative work in bacteriophage-triggered cell suicide systems represents a significant advancement in biotechnology. His contributions continue to influence research and practical applications in the field.