Da-Ming Gou

Title: Da-Ming Gou: Innovator in Chemoenzymatic Synthesis

Introduction

Da-Ming Gou is a notable inventor based in Kingston, RI (US). He has made significant contributions to the field of chemistry, particularly in the area of chemoenzymatic synthesis. With a total of 2 patents, his work has advanced the understanding and application of complex biochemical processes.

Latest Patents

Gou's latest patents include innovative methods for synthesizing the taxol C-13 side chain. His work on the chemoenzymatic synthesis of the taxol C-13 side chain N-benzolyl- - (2R,3S)- and (2S,3R)-enantiomers of trans-.beta.-phenylglycidic esters demonstrates a high yield in the synthesis process. Additionally, he has developed D-myo-inositol 1,4,5-trisphosphate analogues through a chemo-enzymatic route. These 6-O-substituted analogues maintain the biological activity of Ins(1,4,5)P.sub.3 and are capable of eliciting Ca.sup.2+ release from porcine brain microsomes. Furthermore, these analogues facilitate the preparation of Ins(1,4,5)P.sub.3-based immunogens and affinity matrices, which are instrumental in the purification of antibodies against Ins(1,4,5)P.sub.3.

Career Highlights

Throughout his career, Da-Ming Gou has worked with esteemed organizations, including the Board of Governors for Higher Education in the State of Rhode Island. His contributions to the field have been recognized and valued in various academic and research settings.

Collaborations

Gou has collaborated with notable colleagues such as Ching-Shih Chen and Yeuk-Chuen Liu. These partnerships have further enriched his research and innovation efforts.

Conclusion

Da-Ming Gou's work in chemoenzymatic synthesis has made a significant impact in the field of chemistry. His innovative patents and collaborations highlight his dedication to advancing scientific knowledge and applications.