Company Filing History:
Years Active: 1982-1987
Title: D Eugene Wampler: Innovator in Hepatitis B Research
Introduction
D Eugene Wampler is a notable inventor based in Harleysville, PA (US), recognized for his contributions to the field of biotechnology. He holds two patents that focus on the immunogenic properties of hepatitis B surface antigens. His work has significant implications for vaccine development and the treatment of hepatitis B.
Latest Patents
Wampler's latest patents include "Immunogenic HbsAg derived from transformed yeast" and "Separation of hepatitis B surface antigen." The first patent describes a method for synthesizing the surface antigen protein of the human Hepatitis B virus in Saccharomyces cerevisiae. This process results in a polypeptide that is essentially free of intermolecular disulfide bonds. The patent highlights the conversion of this antigen into a fully intermolecular disulfide bonded particle, enhancing its immunogenicity by approximately ten-fold. The second patent focuses on the concentration and separation of hepatitis B surface antigen from contaminating materials through ultrafiltration, paving the way for further processing to isolate HBsAg.
Career Highlights
Wampler has made significant strides in his career, particularly through his work at Merck & Company, Inc. His innovative approaches to vaccine development have contributed to advancements in the biotechnology sector. His research has not only enhanced the understanding of hepatitis B but has also provided practical methods for producing vaccines using recombinant DNA techniques.
Collaborations
Throughout his career, Wampler has collaborated with esteemed colleagues, including Arthur Friedman and E Dale Lehman. These partnerships have fostered a collaborative environment that has led to groundbreaking research and development in the field of immunology.
Conclusion
D Eugene Wampler's contributions to hepatitis B research and vaccine development underscore his importance as an inventor in the biotechnology field. His innovative patents and collaborative efforts continue to influence advancements in medical science.