Company Filing History:
Years Active: 2011-2017
Title: Innovations of Csaba Kiss in Protein Engineering
Introduction
Csaba Kiss is a prominent inventor based in Los Alamos, NM (US), known for his significant contributions to the field of protein engineering. With a total of four patents to his name, Kiss has focused on enhancing the stability and folding characteristics of proteins, which has important implications in various scientific and industrial applications.
Latest Patents
Kiss's latest patents include a method for generating polynucleotides that encode enhanced folding variants. This invention provides directed evolution methods aimed at improving the folding, solubility, and stability characteristics of polypeptides. One aspect of this invention involves creating folding and stability-enhanced variants of proteins, including fluorescent proteins, chromophoric proteins, and enzymes. Another notable patent focuses on generating thermostable variants of target proteins through an internal destabilization baiting strategy. This method involves inserting a heterologous, folding-destabilizing sequence within the DNA encoding the protein of interest, allowing for the evolution of protein sequences to overcome destabilization. Additionally, Kiss has developed highly thermostable fluorescent proteins (TSFPs) that exhibit remarkable stability and thermotolerance, retaining significant fluorescence even at elevated temperatures.
Career Highlights
Csaba Kiss is currently associated with Los Alamos National Security, LLC, where he continues to innovate in the field of protein engineering. His work has led to advancements that not only enhance the stability of proteins but also expand their potential applications in various industries.
Collaborations
Kiss has collaborated with notable colleagues, including Andrew M. Bradbury and Geoffrey S. Waldo, contributing to a rich environment of innovation and research.
Conclusion
Csaba Kiss's work in protein engineering exemplifies the impact of innovative thinking in scientific research. His patents reflect a commitment to advancing the field and improving the functionality of proteins for various applications.