Location History:
- Leuven, BE (2009)
- Aberdeen, GB (2009 - 2015)
Company Filing History:
Years Active: 2009-2015
Title: Innovator Cosimo De Bari: Advancements in Connective Tissue Repair
Introduction
Cosimo De Bari is an influential inventor based in Aberdeen, GB, recognized for his significant contributions to the field of biotechnology and regenerative medicine. With a total of six patents to his name, De Bari has focused on developing innovative methods for treating connective tissue defects, showcasing the potential for advanced therapeutic solutions.
Latest Patents
One of Cosimo De Bari's latest patents involves a method for treating connective tissue defects using chondrocytes selected for phenotypic stability. This invention presents an in vivo assay designed to measure anchorage-independent growth along with the phenotypic stability of a specific cell population. The process includes subcutaneous or intramuscular injections in mammals of a cell suspension comprising articular chondrocytes, quantified to an amount of at least 1 × 10 chondrocytes, especially applied in immune-deficient mice. The outcome of this method is linked to molecular markers, enhancing the monitoring and effectiveness of tissue repair strategies. This invention also relates to DNA chips and diagnostic tools that predict the outcomes of autologous chondrocyte transplantation (ACT). Additionally, antibodies raised against both positive and negative markers of chondrocyte stability can be utilized for quality control on these crucial cells. The therapeutic compositions containing stable chondrocytes present substantial potential for improving tissue repair.
Another significant patent focuses on the isolation of skeletal precursor cells. This patent utilizes cartilage-derived morphogenetic protein CDMP-1, or a transforming growth factor β that shares at least 80% homology with CDMP-1, as a marker for identifying skeletal precursor cells from various parts of the mammalian body.
Career Highlights
Throughout his career, Cosimo De Bari has established a notable presence in the biotechnology sector. He has worked with esteemed companies such as Tigenix NV, where he played a crucial role in advancing research and applications related to chondrocyte therapies. His work has not only propelled new therapeutic methods but has also contributed significantly to the understanding of tissue regenerative processes.
Collaborations
Collaboration has been key to Cosimo De Bari's innovations. He has partnered with several renowned professionals in the field, including Frank Luyten and Francesco Dell'Accio, both of whom have contributed their expertise to bolster the research and development of connective tissue repair strategies.
Conclusion
Cosimo De Bari's innovations in the treatment of connective tissue defects highlight the importance of ongoing research and development in regenerative medicine. His patents not only demonstrate his commitment to enhancing therapeutic options but also reflect the collaborative nature of scientific discovery. Through his work, he has paved the way for future advancements in the field, promising improved outcomes for patients requiring tissue repair solutions.