Location History:
- Frederick, MD (US) (1994 - 2010)
- Middletown, MD (US) (2016 - 2019)
Company Filing History:
12 out of 8,684 
1 out of 1 
1 out of 87 
Years Active: 1994-2019
Title: The Innovative Contributions of Connie S Schmaljohn
Introduction
Connie S Schmaljohn is a prominent inventor based in Frederick, MD (US), known for her significant contributions to the field of molecular vaccines. With a remarkable portfolio of 15 patents, she has made strides in developing innovative solutions to combat viral infections.
Latest Patents
One of her latest patents is a gene-optimized Hantaan virus M segment DNA vaccine designed to prevent hemorrhagic fever with renal syndrome. This synthetic, codon-optimized Hantaan virus (HTNV) full-length M gene open reading frame consists of a unique nucleotide sequence encoding HTNV proteins. The synthetic gene was cloned into a plasmid, forming the first optimized HTNV full-length M gene that elicits neutralizing antibodies in animals when delivered in combination with a similarly optimized Puumala virus (PUUV) DNA vaccine. This invention eliminates the need for an extraneous gene sequence that was previously required for the expression of the non-optimized HTNV gene. The synthetic gene is engineered into a molecular vaccine system to prevent hemorrhagic fever with renal syndrome (HFRS) caused by infection with HTNV, SEOV, or DOBV. Alternatively, it can be combined with the optimized PUUV DNA vaccine to protect against HFRS caused by any hantavirus.
Career Highlights
Throughout her career, Connie has worked with notable organizations, including the U.S. Government as represented by the Secretary of the Army and Powerject Vaccines Inc. Her work has significantly impacted the development of vaccines and therapeutic solutions for viral diseases.
Collaborations
Connie has collaborated with esteemed colleagues such as Jay Hooper and Alan L Schmaljohn, contributing to her innovative research and development efforts.
Conclusion
Connie S Schmaljohn's work exemplifies the spirit of innovation in the field of molecular vaccines. Her contributions continue to pave the way for advancements in preventing viral infections and improving public health.