Company Filing History:
Years Active: 1994-1997
Title: Clara N Finch: Innovator in Platelet Glycoprotein Research
Introduction
Clara N Finch is a notable inventor based in Webster, NY (US). She has made significant contributions to the field of biochemistry, particularly in the study of platelet glycoproteins. With a total of 5 patents to her name, Finch's work has advanced our understanding of blood coagulation and related disorders.
Latest Patents
One of her latest patents focuses on mutations in the gene encoding the alpha chain of platelet glycoprotein. This invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha, which have mutations that enhance reactivity with von Willebrand factor. Specifically, the mutation occurs in the hinge region of GP Ib.alpha., such as the substitution of valine for glycine at residue 233. These mutations result in a change in the three-dimensional structure of the mutant polypeptide from a beta bend conformation to an alpha helix formation, creating an amphipathic region within the mutant polypeptide. Additionally, the patent includes DNA encoding the mutant polypeptides and expression systems for their production, along with methods and compositions utilizing these mutant polypeptides and complementary DNA oligomers.
Career Highlights
Clara N Finch has established her career at the State University of New York, where she has been involved in groundbreaking research. Her work has not only contributed to scientific knowledge but has also paved the way for potential therapeutic applications in treating blood-related conditions.
Collaborations
Throughout her career, Finch has collaborated with esteemed colleagues, including Jonathan L Miller and David Cunningham. These partnerships have enhanced her research and expanded the impact of her inventions.
Conclusion
Clara N Finch is a pioneering inventor whose work in platelet glycoprotein research has led to significant advancements in the field. Her innovative patents and collaborations reflect her dedication to improving our understanding of blood coagulation mechanisms.