Location History:
- Wading River, NY (US) (1984)
- East Setauket, NY (US) (1986 - 1993)
Company Filing History:
Years Active: 1984-1993
Title: **Chyng-Yann Shiue: A Pioneer in Radioligand Innovations**
Introduction
Chyng-Yann Shiue, based in Wading River, NY, is a notable inventor with a significant contribution to the field of radioligands. Holding six patents, his innovative work mainly focuses on the development of radioligands labeled with positron emitting radionuclides for dynamic studies in living humans. His inventions aim to enhance the mapping of dopamine receptors, leading to advancements in medical imaging and research.
Latest Patents
Chyng-Yann Shiue's latest patents include the groundbreaking innovations of no-carrier-added (18F)-N-methylspiroperidol and no-carrier-added (18F)-N-fluoroalkylspiroperidols. The first patent discloses a radioligand labeled with a positron-emitting radionuclide, demonstrating extremely high affinity for dopamine receptors. This compound offers enhanced uptake and retention in the brain while reducing radiation burden. These attributes make it a superior radioligand compared to previously known options for mapping dopamine receptors in both normal and disease states in the living brain.
The second patent introduces new radioligands that also feature high affinity for dopamine receptors, with an alkyl group containing 2-6 carbon atoms. Similar to the first, these radioligands provide better uptake and retention in the brain, along with reduced radiation exposure, making them invaluable for studying dopamine receptors in various brain states. Additionally, both patents include new synthetic procedures for these materials, presenting significant advancements in the field of radiopharmaceuticals.
Career Highlights
Chyng-Yann Shiue works with the United States of America, contributing his expertise to propel innovative research and development in radiology and neuroscience. His six patents reflect a successful career dedicated to enhancing the understanding of brain functions through advanced imaging techniques. His work has not only supported scientific progress but also improved the potential for clinical applications that can benefit patient outcomes.
Collaborations
Throughout his career, Chyng-Yann has collaborated with esteemed colleagues, including Alfred P. Wolf and Joanna S. Fowler. These partnerships have fostered an environment of innovation, allowing for the exchange of ideas and knowledge that has significantly advanced the field.
Conclusion
As an accomplished inventor, Chyng-Yann Shiue continues to push the boundaries of scientific research in radioligands. His contributions have paved the way for new methods of mapping dopamine receptors, which play a vital role in understanding various neurological conditions. With a commitment to innovation, he remains a respected figure in the scientific community, promising further advancements in the realm of medical imaging and research.