Chun-Nam Lok

Title: Innovations of Chun-Nam Lok in Antisense Oligonucleotide Technology

Introduction

Chun-Nam Lok is a notable inventor based in Hong Kong, CN. He has made significant contributions to the field of biotechnology, particularly in the development of therapeutic agents that utilize novel oligonucleotide chimera. His work focuses on the selective inhibition of gene transcription and expression, which has important implications for medical research and treatment.

Latest Patents

Chun-Nam Lok holds a patent for "Chimeric antisense oligonucleotides of arabinofuranose analogue and deoxyribose nucleotides." This invention relates to innovative oligonucleotide chimera that serve as therapeutic agents. These agents are designed to selectively prevent gene transcription and expression in a sequence-specific manner. The invention specifically addresses the inhibition of protein biosynthesis through an antisense strategy, utilizing oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanked by deoxyribose nucleotide residues of variable length. The technology aims to hybridize with complementary RNA, such as cellular messenger RNA and viral RNA, to induce cleavage via RNaseH activation.

Career Highlights

Chun-Nam Lok is affiliated with McGill University, where he continues to advance his research in the field of oligonucleotide technology. His work has garnered attention for its potential applications in therapeutic interventions and gene regulation.

Collaborations

Chun-Nam Lok has collaborated with esteemed colleagues, including Masad Jose Damha and Michael A Parniak. These collaborations have further enriched his research and contributed to the advancement of oligonucleotide technology.

Conclusion

Chun-Nam Lok's innovative work in the field of antisense oligonucleotides represents a significant advancement in biotechnology. His contributions have the potential to impact therapeutic strategies for gene regulation and treatment.