Company Filing History:
Years Active: 2021-2025
Title: Christopher Toomey: Innovator in Glycosylation Technology
Introduction
Christopher Toomey is a prominent inventor based in Cambridge, MA (US). He has made significant contributions to the field of glycosylation technology, holding a total of 3 patents. His work focuses on the microbial production of mogrol and mogrosides, as well as the development of uridine diphosphate-dependent glycosyltransferase enzymes.
Latest Patents
One of Toomey's latest patents involves the microbial production of mogrol and mogrosides. This invention provides host cells and methods for making mogrol glycosides, including Mogroside V (Mog.V), Mogroside VI (Mog.VI), Iso-Mogroside V (Isomog.V), siamenoside, and other glycosylation products. The technology offers engineered enzymes and host cells for producing these mogrol glycosylation products at high purity and yield. Additionally, it outlines methods for creating products containing mogrol glycosides, which can be used in food products, beverages, oral care products, sweeteners, and flavoring products.
Another significant patent by Toomey is related to uridine diphosphate-dependent glycosyltransferase (UGT) enzymes. This invention provides UGT enzymes capable of catalyzing the transfer of a monosaccharide moiety from a NDP-sugar to the 3' carbon of a sugar moiety of a substrate, such as a terpenoid glycan. The invention also includes polynucleotides encoding the 1-3 UGT and host cells that comprise these polynucleotides. Furthermore, it presents methods for preparing glycosylated substrates, including steviol glycosides, using the enzyme and host cells described.
Career Highlights
Christopher Toomey is currently associated with Manus Bio Inc., where he continues to innovate in the field of glycosylation technology. His work has positioned him as a key figure in the development of new methods and products that leverage the potential of glycosylation.
Collaborations
Toomey has collaborated with notable colleagues, including Ajikumar Parayil Kumaran and Jason Eric Donald, contributing to advancements in their shared field of research.
Conclusion
Christopher Toomey's innovative