Chidambaram Ramachandran

Title: Chidambaram Ramachandran: Innovator in Genetic Research

Introduction

Chidambaram Ramachandran is a notable inventor based in Pierrefonds, CA. He has made significant contributions to the field of genetic research, particularly in the study of protein tyrosine phosphatases.

Latest Patents

Ramachandran holds a patent for "Protein tyrosine phosphate-1B (PTP-1B) deficient mice and uses thereof." This invention provides mice that have had their PTP-1B genes disrupted by targeted homologous recombination. The mice exhibit no detectable PTP-1B protein but appear physiologically normal. However, they have half the level of circulating insulin compared to their wild-type littermates when fed a normal diet. In glucose and insulin tolerance tests, these mice demonstrate increased insulin sensitivity. When subjected to a high-fat, high-carbohydrate diet, they show resistance to weight gain compared to their wild-type counterparts. The patent also includes methods for creating these mice and cell lines derived from them, as well as methods for identifying inhibitors of PTP-1B enzymatic activity.

Career Highlights

Throughout his career, Ramachandran has focused on innovative research that bridges genetics and metabolic health. His work has implications for understanding insulin sensitivity and obesity, making it relevant in the context of diabetes research.

Collaborations

Ramachandran has collaborated with notable colleagues such as Brian P Kennedy and Paul Payette, contributing to advancements in genetic research.

Conclusion

Chidambaram Ramachandran's work in developing PTP-1B deficient mice represents a significant advancement in genetic research, with potential applications in understanding metabolic diseases. His contributions continue to influence the field and inspire future innovations.