Chia-Liang Yen

Title: Innovations of Chia-Liang Yen in Nanotechnology

Introduction

Chia-Liang Yen is a prominent inventor based in Tainan, Taiwan. He has made significant contributions to the field of nanotechnology, particularly in the development of methods for treating diseases related to protein retention in the endoplasmic reticulum.

Latest Patents

One of his notable patents is titled "Endoplasmic reticulum-targeting nanovehicles and methods for use thereof." This invention presents a method for treating diseases caused by protein retention in the endoplasmic reticulum (ER). The method utilizes a sarcoplasmic/endoplasmic reticulum calcium ATPase pump inhibitor encapsulated in a polymer nanoparticle. The polymer nanoparticle is designed to be surface-modified for targeted delivery to the ER. This innovative approach reduces protein retention in the ER while minimizing side effects, such as cytotoxicity, associated with the inhibitor when administered without encapsulation. Additionally, the patent discloses a pharmaceutical composition for implementing the method and introduces a transgenic mouse model for human chronic granulomatous disease.

Career Highlights

Chia-Liang Yen is affiliated with National Cheng Kung University, where he continues to advance research in his field. His work has garnered attention for its potential applications in medical treatments and drug delivery systems.

Collaborations

He has collaborated with notable colleagues, including Chi-Chang Shieh and Dar-Bin Shieh, contributing to the advancement of research in nanotechnology and its applications in healthcare.

Conclusion

Chia-Liang Yen's innovative work in nanotechnology, particularly his patent on endoplasmic reticulum-targeting nanovehicles, showcases his commitment to addressing critical medical challenges. His contributions are paving the way for future advancements in treatment methodologies.