Company Filing History:
3 out of 611 
1 out of 1 Years Active: 2019-2024
Title: Innovations of Chengqi Yi in DNA Modification and Sequencing
Introduction
Chengqi Yi is a prominent inventor based in Beijing, China, known for his significant contributions to the field of DNA modification and sequencing. He holds three patents that focus on innovative methods for recognizing and marking DNA bases modified by methylation. His work has implications for gene activation, genome editing, and targeted detection of epigenetic modifications.
Latest Patents
One of his latest patents is titled "Tale RVD specifically recognizing DNA base modified by methylation and application thereof." This invention identifies RVDs with recognition preferences for 5mC, 5hmC, and 6 mA, which exhibit different binding properties to these epigenetic modifications. The invention provides an isolated DNA binding polypeptide containing TALEs, a fusion protein, a polynucleotide, a vector comprising the polynucleotide, and a host cell. It also outlines a method for targeting and binding to a target sequence of a gene of interest in a cell.
Another notable patent is the "Method for marking 5-formyl cytosine and use thereof in single base resolution sequencing." This patent discloses a method for marking 5-formyl cytosine, which involves preparing a DNA or RNA sample and mixing it with a buffer solution and a specific compound to achieve the marking reaction. The method can be implemented at a single-cell level, allowing for sequencing at single-base resolution levels.
Career Highlights
Chengqi Yi has worked at prestigious institutions, including Peking University and Edigene Inc. His research has significantly advanced the understanding of DNA modifications and their applications in genetic research and biotechnology.
Collaborations
He has collaborated with notable colleagues, including Bo Xia and Chenxu Zhu, contributing to the advancement of research in his field.
Conclusion
Chengqi Yi's innovative work in DNA modification and sequencing has paved the way for new methodologies in genetic research. His patents reflect a deep understanding of epigenetic modifications and their potential applications in various scientific fields.