Company Filing History:
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Years Active: 1991-2003
Title: Charles Babinet: Pioneer in Gene Replacement Technologies
Introduction
Charles Babinet is a notable inventor based in Paris, France, recognized for his contributions to the field of genetic engineering. He holds three patents that focus on innovative methods for gene replacement and gene conversion in embryonic stem cells. His work has significant implications for the development of transgenic organisms and advancements in genetic research.
Latest Patents
Babinet's latest patents include groundbreaking inventions such as "I-Sce I induced gene replacement and gene conversion in embryonic stem cells." This invention outlines methods for introducing a heterologous DNA sequence into mouse embryonic stem cells through homologous recombination. The process involves creating a double strand break with I-SceI meganuclease, allowing for the generation of transgenic mice that incorporate the desired DNA sequence. Another significant patent is "I Sce I-induced gene replacement and gene conversion in embryonic stem," which describes a method for constructing a villin gene hybrid. This method enhances the frequency of homologous recombination events, facilitating the transfection of eukaryotic cells, particularly embryonic stem cells.
Career Highlights
Throughout his career, Charles Babinet has worked with prestigious institutions such as Institut Pasteur and Institut Curie. His research has contributed to the understanding of genetic manipulation and its applications in various biological fields. His innovative approaches have paved the way for new methodologies in genetic engineering.
Collaborations
Some of Babinet's notable coworkers include Frederic Jaisser and Michel Cohen-Tannoudji. Their collaborative efforts have further advanced the research and development of gene replacement technologies.
Conclusion
Charles Babinet's work in gene replacement and conversion has made a significant impact on genetic research and biotechnology. His patents reflect a commitment to advancing the field and improving methods for genetic manipulation. His contributions continue to influence the scientific community and pave the way for future innovations in genetics.