Location History:
- New York, NY (US) (2008)
- Redwood City, CA (US) (2009)
- Frederick, MD (US) (2014)
- Yantai, CN (2016 - 2020)
Company Filing History:
Years Active: 2008-2020
Title: Innovator Changlin Dou: Pioneering Inducible Eukaryotic Expression Systems
Introduction: Changlin Dou, an accomplished inventor based in Yantai, China, has made significant contributions to the field of biotechnology, holding a total of six patents. His work primarily focuses on the development of innovative systems that enhance the efficiency of genetic expression in eukaryotic cells.
Latest Patents: One of Dou's latest patents involves an "Inducible Eukaryotic Expression System." This invention encompasses compositions and methods that allow for the regulated expression of genes in eukaryotic cells. The expression of a nucleotide sequence of interest, which encodes a specific protein, is managed by a regulatory fusion protein that features both a transcription-blocking domain and a ligand-binding domain. When the appropriate ligand is present, transcription is halted; however, the removal of this ligand allows for the transcription of the nucleotide sequence, facilitating the large-scale production of desired proteins in bioreactor systems.
Career Highlights: Changlin Dou is currently associated with Regeneron Pharmaceuticals, Inc., a prominent biopharmaceutical company known for its focus on developing new medications for various diseases. His innovative work and patents contribute to advancements in biotechnology, particularly in the creation of more efficient gene expression systems.
Collaborations: Throughout his career, Dou has worked alongside notable colleagues such as James P. Fandl and Gang Chen. These collaborations have been instrumental in propelling forward the research and application of his inventions in real-world scenarios.
Conclusion: Changlin Dou's inventive spirit and dedication to biotechnology have led to important advancements in the field. With a strong portfolio of patents, his work on inducible eukaryotic expression systems marks a significant contribution to improving protein production processes, potentially impacting various biopharmaceutical applications. His efforts demonstrate the crucial role that inventors like him play in the ongoing pursuit of innovation in science and technology.